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Month: May 2023

Alzheimer’s breakthrough research from Eli Lilly gives ‘real hope’ to millions of patients and their families

Alzheimer’s breakthrough research from Eli Lilly gives ‘real hope’ to millions of patients and their families

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Eli Lilly has announced that its Alzheimer’s treatment drug has slowed cognitive decline and functional decline in a study, giving millions of patients and their families “real hope that they will have a brighter future fighting this disease.”

The pharmaceutical company on Wednesday shared the results from its TRAILBLAZER-ALZ2 Phase 3 clinical trial of donanemab for the treatment of early symptomatic Alzheimer’s disease.

The drug significantly slowed cognitive and functional decline in patients. Trial participants who received the drug showed a significant reduction in amyloid plaque (a protein associated with Alzheimer’s), a slowing of cognitive decline by 35%, and slowing of functional decline by 40% over 18 months.

These are the “strongest phase 3 data for an Alzheimer’s treatment to date,” according to the Alzheimer’s Association chief science officer.

“This further underscores the inflection point we are at for the Alzheimer’s field,” added chief science officer Maria Carrillo. “The progress we’ve seen in this class of treatments, as well as the diversification of potential new therapies over the past few years, provides hope to those impacted by this devastating disease.” read more

BorgWarner Q1 profits take a hit from electrification R&D, inflation

BorgWarner Q1 profits take a hit from electrification R&D, inflation

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BorgWarner Inc. executives are expecting a boom in the electrification business but not before e-products put some strain on its profitability.

The supplier saw first-quarter sales of $4.2 billion, up 8 percent from a year ago, and net earnings of $230 million, about flat with last year, according to its earnings report Thursday.

While the company increased its sales and earnings projections for the full year, its first-quarter profit results came in just shy of Wall Street expectations, due to inflated costs, high R&D spending on electrification and sagging sales in China, which is also hurting other suppliers with high exposure to the Far East.

“We outperformed the market both in Europe and North America,” CEO Frederic Lissalde said on a call with investment analysts. “As we expected going into the quarter, our margin performance was negatively impacted by our planned e-R&D investment, net inflationary costs and the impact of low production in China.”

BorgWarner, known for its turbochargers, has been working the last few years to shed ties to the internal combustion engine and recast itself as a leading supplier of inverters, batteries and other EV components. To that end, the spin-off of its fuel systems and aftermarket segments — to be renamed Phinia — is expected to be complete by the end of the third quarter. read more

People on the move

People on the move

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Banking

Rick Wells was appointed commercial real estate manager at Intracoastal Bank, Daytona Beach.

Mark Wisniewski was appointed chief lending officer at Intracoastal Bank, Daytona Beach.

Boards of directors

Jarred Fayson, chief executive officer of Sadler Fayson Fulfillment, was appointed to the Climate First Bank board of directors.

Health care

Dr. Tyler Huhn has joined Huhn Dental in Orlando as a dentist.

Technology

Tammy Daigle was hired as chief customer officer at Sign In Solutions, Orlando.

Submit professional appointments, management-level promotions and significant awards for individuals, along with photos as .jpg attachments, to peopleonmove@orlandosentinel.com.