Publix will make COVID-19 vaccine appointments again in metro Orlando, other Florida counties Publix will make COVID-19 vaccine appointments again in metro Orlando, other Florida counties February 23, 2021 dzadmin Comments 0 Comment The online reservation system will open again at 7 a.m. Wednesday for 273 stores in 20 Florida counties, including Orange, Osceola, Lake and Seminole. The new appointments will be for Friday.